Introduction: Hepatocellular carcinoma is one of the few indications for liver transplantation in malignancies. There are different policies for liver transplantation of patients with hepatocellular carcinoma in different centers, but the most accepted criteria is Milan criteria. This study is designed to present our experience in liver transplantation of patients with hepatocellular carcinoma.

Materials and Methods: Between 2008 and 2013, a total of 90 patients including 73 males and 17 females with hepatocellular carcinoma underwent liver transplantation. All the patients had cirrhotic livers and child class B or C who were not candidate for liver resection. 83 patients received whole organ while 7 cases underwent living related liver transplantation. The hepatectomy technique was piggy-back in 39 patients and standard in 51 patients.The underlying cause of cirrhosis was HBV, HCV and cryptogenic in 50 (55%), 8 (9%), and 17(18%) patients, respectively. All the patients were followed for tumor recurrence with intermittent serum αFP measurement and abdominal sonography. The follow-up period was 2-60 months (26 ± 22).

Results: Outcome analysis showed that among 90 patients with HCC, 13 cases (14.4%) expired during the follow-up period in whom 3 cases died during hospital admission. Eight patients (9%) showed tumor recurrence

Conclusions: Hepatocellular carcinoma is one of the common indications for liver transplantation in our center. The initial results show considerable survival benefits in the affected patients.