Introduction: Acute renal injury is a common complication in liver transplant patients. Acute kidney injury is due to nephrotoxic drugs used after liver transplant, infections and hemorrhage. Though it is generally reversible it has effects on grafts and patients survival. In this retrospective observational study carried out at a single centre, effects of acute renal disease on liver recipient’s survival were investigated.
Materials and Methods: Liver transplant, live donor & cadaver, patients between Jan 2002- May 2013 were icluded in this study. The acute kidney disease diagnosis and staging was made based on nephrology department evaluation and daily serum creatinine levels. Patients with acute kidney injury history prior to liver transplant and those undergoing transplantation for the second time were excluded from the study.
Results: 310 liver transplant patients were included in the study. There were 165 male and the remaining 145 were female patients. The patients’ average was 28 (6 months- 62 years age range). Kidney functions were evaluated by the nephrology department 1 week, 3 months and 1 year after liver transplant. Acute kidney disease rates in these patinets was 5%, 8% and 12% respectively. Four patients developed chronic kidney failure during the follow up period. When patients that developed acute renal failure and those that didn’t have this condition were compared mortality rate was higher, 18% in acute renal failure patients. Mortality rate was 11% in patients that had no acute renal failure.
Conclusions: Acute renal injury is quite common after liver trabsplant
and has an important effect on mortality.