Introduction: Today, the 1-year expected survival rate is over 85% and 5-year survival rates of 65-75%. The introduction of cyclosporine markedly improved patient outcomes Introduction: To present 1st cadaveric liver transplant patient with long term follow in Libya, to discuss possibility of cyclosporine withdrawal

Materials and Methods: medical chart of the patient was reviewed, co morbidities were evaluated, and demographic data were collected

Results: The patient is female Egyptian, born in 1950, married, she was known post hepatitis liver cirrhosis, for which she received treatment with standard interferon, cadaveric liver transplantation was in Germany in June 1989, she was started cyclosporine in a dose of 250mg/bd, an now on 50mg with C0 of 40ng/l. She is hypertensive and diabetic

Conclusions: Management of modifiable post-LT factors including diabetes, hypertension and renal insufficiency may impact long-term mortality. Immunosuppressive weaning affects long term survival, an its withdrawal is the future decision.