Introduction: Patients with neuroendocrine tumors (NET) often present with synchronous liver metastases or develop hepatic metastases in the course of the disease.

Case Report: We report a case of liver transplantation (LT) in a 37 years old female patient with hepatic metastases originating from neuroendocrine carcinoma of pancreas. She had distal pancreotectomy and splenectomy 6 months before LT and diagnosed as well differentiated neuronedocrine carcinoma histopathologically. At the same time multiple metastatic nodules which were infiltrating nearly the whole liver was noted in the abdominal CT and the biopsy of these metastatic nodules revealed the same diagnosis with the pancreas tumor. Thus LT became the only therapy option for the patient. After LT she had only one rejection episode during follow-up and neither reccurence nor metastasis was found during 6 years follow-up.

Conclusions: Metastatic tumors of the liver have been considered to be a poor indication of LT. But neuroendocrine tumors have biologically less agressive nature throughout the life span. LT appears to be a therapeutic approach which should be considered for selected patients with unresectable metastatic hepatic disease originating especially from endocrine tumors of pancreas.