Introduction: More than dozen frequently used immunosuppressive agents in liver transplantation with various target pathways are known and Cyclosporine (CsA) is a potent immunosuppressant drug which is widely used to prevent graft rejection after transplant. Overproduction of reactive oxygen species is one of the side effects of CsA that might cause severe damages primarily to the liver and kidneys. Also CsA treatments produce a significant increase in the serum urea and creatinine levels. Previous studies show that Pyrus boissieriana buhse leaves extract (Telka EXT) and Arbutin (ART) have antioxidant properties. We present the potential protective properties of ART in isolated rat that pretreatment by CsA.

Materials and Methods: Sixty four male wistar rats (250-300 g) divided into eight groups: Two doses of CsA (25 and 50 mg/kg), EXT (500 mg/kg), Arbutin (50 mg/kg), and distilled water (control). We analyzed serum urea and creatinine levels after the completion of treatment process.

Results: We report that the serum urea level in coadministration of ART and CsA at a dose of 50 mg / kg was significantly lower than its level in coadministration of EXT and CsA50 (p = 0.01). Urea level in administration of ART50 was lower than its level in coadministration of ART50 and CsA50 (p = 0.003). Although we found no statistically significant difference between the group which received only Arbutin and the control group (p = 0.282). Serum

Creatinine level was significantly higher in the administration of Arbutin 50 in comparison to the other groups (p < 0.05), but creatinine level in the groups that received only EXT was meaningfully lower than the rest (p < 0.05).

Conclusions: We conclude that EXT could diminish the side effects of CsA treatment by reduction of the serum urea and creatinine levels. These results suggest that EXT might be a potential adjunctive agent for the receiver CsA patients as an important parameter in liver transplantation.