Three-fold increase in induction therapy was noticed over the last decade. The objectives for induction therapy is to augment immunosuppression, facilitate delay introduction of calcineurin inhibitors, allow minimization / avoidance strategies of steroids and /or calcineurin inhibitors, beside its important role in desensitization protocols and ABO incompatibility transplants.

Different agents utilized for induction therapy will be highlighted in some details.

The conclusion will stress on induction therapy evaluation and its impact on outcome.

I think that till the end of 2013 the final chapter of induction therapy is not yet written.