Establishment of compensated and regulated living unrelated renal transplantation in Iran in 1988 resulted in decreasing number of patients in the waiting list. A cohort study for evaluation of long term medical complications of donors has been designed by Academy of Medical Sciences of IRAN in June 2006. This is a preliminary report of donors follow up (F/U) program. Living unrelated kidney donors who had donated their kidneys since June 2006 were asked to participate in a 10 years cohort study. Demographic characteristics (age at time of nephrectomy, gender), BMI, systolic and diastolic blood pressure and laboratory findings including fasting plasma glucose( FPG), hemoglobin(HGB), BUN, serum creatinine(Cr), uric acid, lipid profile and urinalysis are recorded in every visit. Urine protein to urine creatinine ratio will be reported in patients after 1 year F/U. GFR is estimated by Cockroft- Gault formula. Control healthy subjects of the same age will be followed up in parallel with donors. A total of 408 donors were registered (79.7% male and mean age 28.7 ± 5 years) that 3.7 ± 3 months had passed since their nephecrtomy. Ninety donors completed 12 months follow-up until now. Among these patients, HGB (13.7 ± 1.4 mg/dl vs. 14.6 ± 1.3 mg/dl), hematocrite (41% ± 4.1% vs. 43.9% ± 5.1%) and GFR (83.9 ± 15.7 cc/min vs. 117 ± 29.1 cc/min) increased significantly after F/U. There were no statistically significant differences regarding other clinical and laboratory findings before and after follow up. This preliminary report of 1 year F/U of LURDs revealed early drop in GFR was compensated by increased GFR at 1 year. These donors will be followed up annually until 10 years and in the future long term outcome of LURDs in Iran will be reported.