Infective endocarditis (IE) is a rare but life threatening infection after renal transplantation. Therefore, the current study was initiated to determine the outcome of kidney transplant patients hospitalized for bacterial endocarditis. In a retrospectively study, we analyzed the medical records of 3700 kidney transplant recipients at two major transplant centers in Iran, between January 2000 and June 2008 for infective endocarditis. During the study, 15 patients with IE hospitalized in our centers, were included if they met the modified Duke’s criteria for definite IE. Data were gathered for patient age and sex, the source of the donated kidneys (deceased versus living donor), immunosuppressive regimen, clinical presentation of infective endocarditis, time presentation since transplantation, comorbid conditions, treatment modalities, the patient’s response to treatment, and the effect of IE on graft and patient survival In-hospital and 6-month mortality rate were 33.3% (n = 5). Patient survival rate in all recipients was 66% at 6 months. The spectrum of organisms causing infective endocarditis was obviously different in transplant recipients than in the general population; the most common causes of IE (60% of the infections) were due to group D streptococci and enterococci. The majority of our recipients had mitral (n = 9) and aortic valve (n = 8) endocarditis, and twenty percent (n = 3) of IE episodes presented with two infected valvular sites. Rapid diagnosis, effective treatment, and prompt recognition of complications in kidney transplant recipients are essential to good patient outcome. The mortality rate in the current study was lower than the previous reports.