The incidence of Kaposi's sarcoma (KS) is higher in organ transplant recipients. The lesions are mainly cutaneous and isolated mucosal involvement is rare. We herewith report a 26-years-old male patient, who underwent a living unrelated donor renal transplantation for chronic interstitial nephropathy. His immunosuppression protocol consisted of corticosteroids, cyclosporine & immuran. Twenty-five months later, presented with a purple hyperplastic lesion and mucosal nodules more than 8 mm in diameter in hard palate and gingiva of oral cavity. He reported that the lesion had been present for 1 month. Further examination confirmed that no similar lesions were present on his skin. Computed tomography of the oral cavity revealed multiple lytic bone lesions. Histological examination coupled with immuno­histochemistry was suggestive of KS. The patient tested positive for anti-Herpes Human Virus antibodies. Cyclosporine & immmuran were withdrawn and rapamycin was introduced. This resulted in a regression of both mucosal and bone KS in two to three month. Two-years fallow up didn’t show any effect of flair up of KS. Our case suggests that rapamycin-based immunosuppression offers a promising approach to the management of post-transplant KS, particularly with mucosal involvement.