The quality of harvested organs has a great impact on outcome of transplantation. Hypernatremia have previously been shown to affect the outcome of liver transplantation. Increased level of creatinine in donors is also associated with delayed graft functioning in kidney recipients. Such pre-transplantation situations in donors could be corrected in many cases with proper care of the brain dead patients. The aim of the current study is to investigate the presence of such conditions in brain dead patients and the result of intensive care to correct the situation. We retrospectively reviewed hospitalization record of 93 brain dead patients in our center. Data regarding serum level of sodium and creatinine were extracted at the time of transferring the brain dead patients to transplantation ICU and later at the time of organ harvest. We used paired-sample t-test to compare ICU admission values with pre-harvest ones. The mean serum Na at the time of admission to transplantation ICU was 152.9 ± 13.2 mEq/L that decreased to 148.1 ± 11.6 mEq/L at the time of procurement surgery (p= 0.001). The mean serum creatinine also decrease from 1.8 ± 1.1 mg/dL at transplantation-ICU to 1.6 ± 1.3 mg/dL at procurement procedure (p<0.001). In our study, we found that the serum level of sodium and creatinine have been decreased during hospitalization in transplantation ICU. We believe that proper care to brain dead patients could correct the undesirable condition of the patients and result in a harvested organ of better quality.