Brain dead patients, due to their critical condition, may easily develop complications that could interfere with organ donation. One of these complications is thrombocytopenia. Thrombocytopenia due to different etiologies may lead to massive hemorrhage that threatens the organ donation process. The aim of the current study is to evaluate the presence and severity of thrombocytopenia in brain dead patients and its effect on organ donation process. We retrospectively searched the records of brain death patients at Organ Procurement Unit of Shaheed Beheshti University, Tehran, Iran. All 93 cases from January 2005 up to the present time were evaluated for the presence of thrombocytopenia. Based on their platelet count, they were categorized to normal, thrombocytopenic (50,000< care. proper receives patient the if safe and feasible is thrombocytopenia, of grades severe with even patents, thrombocytopenic in harvest organ that believe authors The hemorrhage. spontaneous risk a has who thrombocytopenia those observed not was donation on effect negative procedure procurement during before hemorrhage including complication Serious patients. dead brain high rate we Discussion: group. studied among organs harvested number difference significant no There bleeding. had 5.4% bleeding increase patients 16.1% 63.4% Thrombocytopenia Results: test. ANOVA one-way using regarding outcome compared evaluated also We 20,000). count (Platelet 50,000) Platelet (20,000 150,000), count<>