Transplantation is a successful procedure in prolonging the lives of people suffering from debilitating diseases .The purpose of this study was to assess medical students' attitudes toward organ donation and their willingness to donate their own organs or those of a deceased relative. The study population consisted of 262 medical students from all 7 years of medical course, with mean value of age 22.1 ± 2.5 years who were surveyed using a reliable questionnaire included attitude and willingness measures. All data analyses were carried out using the SPSS , Chi-square and ANOVA tests. The medical students had highly positive attitudes toward organ donation (mean score 4.31 ± 0.46) and a great willingness to donate tissues and organs(85% of total students). Participants were more willing to donate their own organs than those of a deceased relative(85% vs 49.2%) and in order to helping others than the development of science(91.2% vs. 8.8%). Students were willing to donate all organs and tissues, but the most willingness was blood (89.3%) and kidney (84%) donation .There was no correlation between age, gender, level of education and attitude toward organ donation. In conclusion, these findings necessitate an organized education program of medical students in all aspects of organ and tissue donation.