To evaluate the effect of parenteral vitamin E on renal ischemia-reperfusion injury, 20 German rabbits weighting 1.5-1.9 kg were selected and divided into 2 case and control groups. Each group contained 5 male and 5 female rabbits. Intravenous vitamin E is administered to case group five minutes before left renal artery clamping and the same volume of normal saline was injected to control group. Ischemia was maintained for 60 minutes. After 48 hours nephrectomy was performed and kidneys were sent to pathology laboratory. Histopathologic sections were evaluated by the pathologist and graded by the extent of tissue injury to normal, mild and mode rate to severe injury. Histopathologic evaluation of the sections revealed that in control group 50 % of sections had signs of moderate to severe injury and 50% categorized as mild injury whereas 50% of case group sections developed no sign of ischemia-reperfusion injury and 50% developed mild injury (p value = 0.033). There is also no significant correlation was found between sex and the extent of cell injury (p value = 0.99). In conclusion, Parenteral injection of vitamin E significantly protects cells against ischemia reperfusion injury.