Liver cirrhosis is the terminal condition of liver disorders resulting from various causes. Literature lacks data on epidemiological and clinical aspects of liver cirrhosis in Iran. Clearly, Iran has a high prevalence of viral hepatitis. It is clear that we need to know all the clinical and epidemiologic characteristics to propose national actions to try to control and prevent this disease. Because of the important role of etiologic factors in the management and treatment of cirrhotic patients and early diagnosis of liver disease in family members for prevention of disease, we should have accurate information about epidemiology and etiologic factors of cirrhosis. We aimed to evaluate the main features of liver cirrhosis in this study. A retrospective study was done on cirrhotic patients underwent liver transplantation from 1991 till 2008 in Namazi Hhospital, Shiraz, Iran. The records of 225 patients were reviewed for finding the etiology of cirrhosis according to their age; sex; personal and family history; labrotory tests and radiologic studies. Then etiologies were classified according to sex and age. To find incidental pathologic findings; liver of recipients were reviewed by two experienced pathologist. Data were entered in spss ver: 13 and analyzed. Charts of 225 patients including 79 women and 146 men with mean age 31.8(range 2-62 years) were reviewed. The etiologic spectrum consisted of chronic hepatitis B 44 (19.6%), autoimmune hepatitis 41(18.2%); primary sclerosing collangitis 29(12.9%); Wilson 23(10.2%); chronic hepatitis C 8 (3.6%); cryptogenic cirrhosis 55 (24.4%); hepatocellular carcinoma and cholangiocarcinoma (each in .4%);primary biliary cirrhosis 3(1.3%)and alcoholism 2 halothane toxicity; thyrosinemia, Byler’s disease (each in 0.9%);congenital hepatic fibrosis 1(0.4%). In women the most common etiologies were autoimmune hepatitis; cryptogenic cirrhosis and primary sclerosing collangitis respectively. But in men hepatitis B and C were the main etiologies of liver failure. In age group under 15 years autoimmune hepatitis and secondary cholestasis; group 15-30 autoimmune hepatitis and then Wilson and in age group 31-50 and older than 50 years hepatitis B virus were the most prevalent etiologies in our study. (table 1) The most common incidental pathologic findings were chronic hepatitis and secondary cholestasis (each in 7 cases) and then hepatobiliary carcinoma (3) cases. In conclusion liver cirrhosis principally affects males. Most patients were between 31-50 years. The principal known cause is chronic viral hepatitis (B). Despite high prevalence of alcoholism in west, alcoholic cirrhosis is not a common cause of chronic liver failure in our country. Autoimmune hepatitis is the main cause of cirrhosis in children under 15 years like other studies in Iran.