It is well recognized that graft dysfunction immediately post-transplant can vary from a subtle slowing of the expected decline in Cr to frank oliguria requiring dialysis for days to weeks. Identified risk factors for slow and DGF have included prolonged preservation, increased donor age, and high recipient PRA. Cyclosporine nephrotoxicity is one of the other causes of early post transplant kidney allograft dysfunction. The aim of the this study was evaluation of the early kidney allograft function in patients who were on cyclosporine 48 h before transplant surgery and compare it with recipients who received cyclosporine after improvement of allograft function. In a comparative study, 62 kidney allograft recipients from living unrelated donors were divided into two groups based on the time of cyclosporine beginning. Group 1: kidney allograft recipients who received cyclosporine from 48 h before transplant surgery (100 mg BID). Group 2: patients who had received cyclosporine after transplantation when allograft function improved (serum creatinine < 3mg/dl). Others immunosuppressive medications were the same in both groups. Statistical analysis was performed using SPSS version 14 to compare kidney allograft function within the first month after transplantation in two groups. The results showed: group 1: Mean blood urea and serum creatinine were 73.72+/- 31.00 mg/dl and 5.11 +/- 1.83 mg/dl, the day after transplantation that was that was reduced to 49.61 +/-12.18 mg/dl and 1.22+/- 0.28 mg/dl at the end of admission respectively. Mean 24 h urine volume was also 11052 +/- 4290 ml the day after transplantation and 3202+/- 986 ml at the end of admission. Group 2: Mean blood urea and serum creatinine were 87.52 +/- 29.82 and 6.42 +/- 3.64 the day after transplantation that reached to 69.11 +/- 33.76 mg/dl and 1.47+/- 0.79at the end of admission respectively. Mean 24 h urine volume was also 9629 +/-4530 ml the day after transplantation and 3095 +/- 726 ml at the end of study. There was no significant difference regarding the age, gender and immunosuppressive medications between the two groups. In conclusion it seems that early and low dose cyclosporine administration before transplant surgery accompanied with well preserved early allograft function without any deleterious effect.