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Volume: 6 Issue: 4 November 2008 - Supplement - 1

FULL TEXT

POSTTRANSPLANTATION LYMPHOPROLIFERATIVE DISORDER AFTER LIVER TRANSPLANTATION:
A SINGLE CENTER EXPERIENCE AMONG 500 PATIENT SERIES

Posttransplantation lymphoproliferative disorders (PTLD) are defined as polyclonal or monoclonal proliferations, mostly of B cells, which occur after solid organ transplant. Herein we report four liver transplant patients who developed PTLD in the early post transplant period. We retrospectively analyzed four cases of PTLD after liver transplantation among more than 500 liver transplants in our center. Two in pediatric age group and two adult with tyrosinemia, autoimmune hepatitis and HCV hepatitis as the primary cause for cirrhosis respectively. All the cases were diagnosed during the first year after liver transplantation. The patients were diagnosed as PTLD, B cell type, MALT type and Hodgkin’s like. The two pediatric patients died in spite of discontinuing immunosuppressive drugs and chemotherapy.In conclusion, Incidence of PTLD in our center is lower than previous reports (0.8%) with 50% mortality rate and worse prognosis in pediatric age group.



Volume : 6
Issue : 4
Pages : 29


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Shiraz Transplant Center, Namazi Hospital and Transplantation Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.