There is always a fear that cardiopulmonary resuscitation in brain dead patients could inflict such injuries to patients’ heart that make it unsuitable for transplantation. This is while organ shortage forces specialists to retrieve more organs from brain dead patients. The aim of the current study is to find if cardiopulmonary resuscitation (CPR) in brain dead patients have an effect on the number of harvested hearts. In a retrospective design, the hospitalization documents of all brain death patients in Masih Daneshvari Hospital from January 2005 to July 2008 were surveyed for evidences of CPR during hospitalization. Patients were grouped into those with CPR during the hospitalization course and those without CPR. We then surveyed to see if the number of harvested hearts is different between the two groups. During the hospitalization, CPR procedure was performed in 24.7% of brain dead patients. The harvest rate of hearts in the group of patients without CPR was 75.9%. This figure in patients with CPR history was 73.9%. There was no significant difference in the rate of heart donation between the two groups (p=0.53). The result of our study showed that CPR procedure in brain dead patients have no negative effect on the rate of heart donation. Regarding the fact that brain dead patients have usually unstable condition and may require CPR in the course of hospitalization, our finding shows a good promise in the face of organ shortage for transplantation.