Acute rejection is the most critical post-kidney transplant complication occurring in approximately, 30-50 % of recipients. In this study we analyzed some immunological indicators namely sCD30, IL-4, IL-10 that may help in predicting acute rejection before the operation. Eighty pre- transplant patients' sera were collected from the Immunology Laboratory Hamad Al-Essa Kidney and Organ Transplant Center at Sabah Hospital in Kuwait, and analyzed in the Immunology labs of the Arabian Gulf University and the Salmaniya Medical Complex in Bahrain. The study populations were divided according to biopsy findings into forty acute rejection group (AR), and forty no rejection (No-R) group. The sera of both populations were analyzed for sCD30, IL-4, IL-10 using commercial ELISA kits. Five patients of AR group and six in No-R group had very high sCD30 but with no significant difference, yet according to Banff criteria 4 with tubulointerstitial rejection, and 36 with vascular rejection had detectable levels with a higher mean value in the later. IL-4 was not detectable in any of the 80 sera, while 3 patients had positive IL-10 serum levels in AR group and 3 in No-R group. The data of the present study suggest that pre-transplant sCD30, IL-4, IL-10 could not be used as immunological indicators to predict the acute rejection event.