Beta 2- micro globulin is a low –molecular weight protein (11800 Daltons) and found in all biological fluids. It is the light chain of histocompatibility class 1 and present on the membrane of most cells. The presence of class 1 HLA antigen plays a role in the elimination of the virus after infection with hepatitis viruses. Graft versus Host Disease (GVHD) is the important complication of bone marrow transplantation (BMT). We tried to evaluate plasma B2MG level in allogeneic BMT recipients. In this study we measured serum B2MG level by ELISA Kit in serum of 39 patients before transplantation and on 3, 10, 17, 24, and 30 days after BMT. 16 female November41) and 23 male November59) between 8-52 years and 28 healthy control in same age range were included. Our study showed β2 MG level increased in 15(38/2%) patients after BMT that was significantly differed from healthy control. (p=0.0001). In conclusion, it seems that serum β2MG is a good marker for Bone marrow Transplant (BMT) recipients The role of β2MG in monitoring of response therapy needs more evaluation.
Volume : 6
Issue : 4
Pages : 203
Hematology-Oncology and Bone Marrow Transplant Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran