Death is a non-reversible and the worst outcome of transplantation. Knowledge of mortality causes and related factors in patients who had successful and functioning lung transplantation is essential to provide a better care and implement better management measures.We reviewed the re-hospitalization charts of the lung transplanted patients at our lung transplantation center from 2000 to 2008. We looked for records of patients who were re-hospitalized in our center after having successful lung transplantation in the past. The outcome of hospitalizations along with the patient’s characteristics and disease specifications were extracted. For statistical analysis we used descriptive methods and for comparison between those re-hospitalizations that led to death and those which led to recovery, we used Mann-Whitney U and Chi-square tests. During the specified period 13.8% of the complications that needed re-hospitalizations led to death. The cause of admission in 50% of cases which led to death was acute rejection accompanied with infection. All the patients that died were admitted to transplantation ICU. 12.5% of cases with infection, 22.2% of case with acute rejection and 33.3% with concomitant infection and acute rejection as the cause of re-admission died during hospitalization. The mean age of transplantation in cases that led to death was 446.3 ± 171.9 days which is higher compared to those who survived (233.5 ± 176.1; p= 0.049). Acute rejection and infection were the main causes of mortality after re-hospitalization in lung-transplant re-hospitalizations. Hospitalizations with transplantation ICU admission and those related to patients with longer transplant age are at greater risk of undesirable outcome.