Despite dramatic improvement in pre-transplant metabolic abnormalities following successful kidney transplantation, uric acid metabolism is interfered by cyclosporine and hyperuricemia is commonly encountered in post-transplantation era. In a cross sectional study serum uric acid level was assessed in the latest referral of all children who had been transplanted in our center and had regular pediatric nephrologist follow up. Hyperuricemia was defined as serum uric acid level>6mg/dl or allopurinol consumption by the recipient. To remove the effect of allograft dysfunction on the serum uric acid level only children with serum creatinine <1.5mg/dl enrolled in this study. SPSS15.1Soft wear were used for statistical analysis. One hundred and thirty eight out of 216 children ≤19 years at the time of transplantation who was followed by pediatric nephrologist, were involved in this study. There were 79(57.2%) boys and age at Tx was 3-19 years with a Mean+/-SD of (13.6+/-3.5) and minimum weight of 10 kg. Donor ages were 1to52 years with a mean of (24.6+/-12.5)with 41 parents, 9 siblings and other relatives, 67 deceased and 21unrelated. Their Primary renal diseases consisted of glomerular diseases, hereditary diseases, reflux-obstruction dysplasia, stone and unknown in 26(19%), 47(34%), 58(42%), 2(1.5%) and 5(3.5%) respectively. The mode of dialysis before transplantation was hemodialysis in the majority of our cases (85.5%), followed by preemptive transplantation (12.1%). One hundred and thirteen had functioning grafts and in 88 of them serum creatinine were ≤1.5mg/dl. Forty three (48.8%) of the children had either serum uric acid >6mg/dl or they were on allopurinol for their Hyperuricemia. There were 49 male and 39 female with 27(45.8%) and 16(41%) hyperuricemic respectively. Long term survivors were more hyperuricemic so that in children with a 3, 4-6 and >6 years of follow up prevalence of Hyperuricemia was 16.6,51 and 56% respectively. In conclusion, hyperuricemia is quite common following pediatric Kidney transplantation and long term survivors are more hyperuricemic.
Volume : 6
Issue : 4
Pages : 182
Shiraz Transplant Center, Namazi Hospital, and Nephrology- Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran