Organ transplantation recipient immunosuppressed for preventing organ rejection that can predispose them to develop opportunist infections like TB. TB Incidence in patients who have received an organ transplant all over the world vary from %0.35 to %15.TB is a very important infection specially in developing countries that accompanies significantly high mortality and morbidity rates in transplanted patients as compared with the normal population. In most cases the clinical and laboratory findings are elusive and misguiding which further compromises diagnosis. This study was designed to evaluate the clinical and laboratory manifestations of TB in kidney transplanted patients and give more information to clinicians regarding this issue. This descriptive and analytical study was conducted on TB infected patients with kidney transplantation in Babol from 2001 to 2007 through sampling census method along with assessing the hospital records of 17 patients. All clinical and laboratory findings from records were assessed. Finally all statistical calculations were done with SPSS 11. The 17 patients assessed consisted of 11 females (%64.7) and 6 males (%35). The mean time between kidney transplantation and onset of symptoms was 11.35 months. Proportions of clinical findings are following: fever in 8 patients (%47.1), cough in 10 patients (%58.8). Laboratory findings of patients are followings: leukocytosis in 4 patients (%23.5), leucopenia in 4 patients (%23.5) increased ESR in 16 patients (% 94.1), CRP in 12 patients (%70.6), in anemia in 15 patients (%88.2) and thrombocytopenia in 2 patients (%2.8). Results of diagnostic tests assessment are as follows: positive PPD prior to transplantation in 4 patients (%23.5), positive smear staining in 14 patients (%82.4) and positive culture in 8 patients (%47.1). In assessing antiviral antibodies, only one patient was positive for HCV Ab and 10 patients for CMV Ab. HIV testing with ELISA and HBS Ag all were negative. There was no statistically significant difference between smear and clinical findings. In conclusion, TB is a common problem in kidney transplanted patients and its early diagnosis can lead to successfully treatment. In previous studies the mean interval between kidney transplantation and developing of TB infection had been one year that confirms our results. With TB the patients’ prognosis chemotherapy prophylaxis is recommended in high risk patients and several therapy regimens had been suggested.
Volume : 6
Issue : 4
Pages : 175
Babol University of Medical Sciences, Babol, Iran