Renal transplantation is a novel renal replacement therapy for many who suffer from established kidney disease (EKD). Many of these patients have multiple diseases in addition to EKD, which requires complex medication regimens including immunosuppressive therapy. Involvement of a clinical pharmacist as a member of multidisciplinary team in the management of patients undergoing kidney transplantation has great impact on clinical outcomes. The challenge for renal clinical pharmacist, therefore, is to obtain the right knowledge of the complex drug regimens used by renal transplant patients. The services provided by renal clinical pharmacists comprises individualizing patients immunosuppressive therapy, identifying adverse drug reactions and any other drug therapy problems, enhancing patient compliance, advice on therapeutic drug monitoring, educating other health care members on different aspects of medications. The goal of this presentation is to highlight on the main roles of the renal clinical pharmacist in order to improve quality of care provided to patients with EKD in a nephrology ward at the Royal Hospital in Sultanate of Oman.