Serum levels of tumor markers would be altered in patients with kidney transplantation, hemodialysis status and chronic renal failure. Tumor markers are considered as significant diagnostic and prognostic factors in evaluation of various neoplasia. Under normal conditions the levels of these molecules remain low and their metabolism has not been fully clarified. In the present study 27 hemodialysis patients, 27 transplanted patients, and 27 healthy matched individuals have been selected. Their serums were taken and kept in -20°C until the tests would be performed. Then the serum levels of CEA, AFP, CA125, CA19-9, CA15-3 and PSA were measured. There were no significant fluctuations in the level of tumor markers AFP and PSA in the study groups. In hemodialyzed patient group CEA levels exceeding from the normal range in 33% of patients, CA125 in 18.5%, CA19-9 in 18.5%, CA15-3 in 11.1% of patients. In transplanted patients CEA levels exceeding from the normal range in 29.6%, CA125 in 14.8%, CA19-9 in 3.7%, CA15-3 in 3.7% of patient group. The tumor markers would increased in some transplanted or hemodialyzed patients. However, it is difficult to conclude that this augmentation of tumor markers be due to real tumor establishment situation, and seems need alternative method for confirmation any mass development.