The following study was designed to evaluate xenogenic bovine demineralized bone matrix (DBM) and new xenograft (Bovine fetal growth plate) effects on bone healing process. Twenty male White New Zealand rabbits were used in this study. In group I (n=10) the defect was filled by xenogenic DBM and in xenograft group the defect was filled by a segment of bovine fetal growth plate and was fixed by cercelage wire. Radiological, histopathological and biomechanical evaluations were performed blindly and results scored and analyzed statistically. Statistical tests did not support significant differences between two groups radiographically (P> 0.05). There was a significant difference for union at the 28th post operative day radiologically (P<0.05). Xenograft was superior to DBM group at the 28th postoperative day for radiological union (P<0.03). Histopathological and biomechanical evaluation revealed no significant differences between two groups. In conclusion the results of this study indicate that satisfactory healing occurred in rabbit radius defect filled with xenogenic bovine DBM and xenogenic bovine fetal growth plate. Complications were not identified and healing was faster in two grafting groups.