Organ transplantation science has a history of more than a century. Despite many advances in techniques and care of the patients which led to improvement in survival and quality of life in transplanted patients, it has not reached to it’s ultimate goal: transplantation of every patient in need. Among the obstacles in the way is the general belief. Organ transplantation is still a taboo among many individuals and societies. We report here ideas regarding organ transplantation from a general population from Iran. In a cross-sectional study, a group of 87 participants were selected from the general population in Tehran, Iran, 2008. The mean age of the participants was 27 ± 9.8 years (range: 19 to 68). 33(37.9%) of participants were male. A questionnaire containing 38 questions which asks about knowledge, attitude and practice of the participants regarding organ transplantation was given to the participants. We describe here the participants’ answers. 89.2% of the participants were willing to donate their own organs. Among those who opposed organ donation, personal believes consisted 88.8% of cases and religious believes were the cause in only 11.2%. 51.8% of participants believed that a brain dead patient is definitely dead and 9.4% were against this idea. 54.8% of the participants believed that if a person is willing to donate his/her own organs, it should be done regardless of the family’s opinion. We observed that the majority of surveyed Iranian participants support the organ donation. The main reason for opposing the transplantation was personal beliefs.