Preconditioning by brief exposure to ischemia not only protects the organ against subsequent severe ischemia damage but also has protecting effect on other organs which is called remote preconditioning. Our aim in this study was to evaluate the protecting effect of brief liver ischemia on pancreas tissue against severe ischemia/reperfusion-induced pancreatitis. This study was performed on 30 male wistar rats. Ischemic preconditioning of liver was performed by clamping of hepatic pedicle for 10 min and ischemia/reperfusion of pancreas was performed by 30 min clamping of inferior splenic artery and then 1hr reperfusion. Rats were divided into three groups (10 rats in each group). One group as sham operated group without clamping of any artery. The second group underwent ischemia/reperfusion induced pancreatitis without ischemic preconditioning of liver and the third group underwent ischemic preconditioning of liver and then ischemia/reperfusion of pancreas. Ischemic preconditioning, applied prior to induction of pancreatitis, caused the and histological signs ofreduction in plasma lipase, plasma interleukin-1 pancreatic damage but plasma interleukin-10 were not significantly different between groups. Ischemic preconditioning of liver was not caused any alteration on liver enzyme. We concluded that ischemic preconditioning of liver reduces the severity of ischemia/reperfusion induced pancreatitis. These effects are partly related to the reduction of proinflammatory interleukin -1.
Volume : 6
Issue : 4
Pages : 162
Shiraz Transplant Center, Namazi Hospital, and Transplantation Research Center, Shiraz University of Medical Science, Shiraz, Iran