The safety of the healthy donor must be the first consideration during living-donor liver transplantation (LDLT). There are data demonstrating a gender dimorphic response of the liver, favoring female liver, for various stresses. However, it is not clear whether this information may translate into improved outcome in clinical setting. The aim of this study was to determine whether the gender of donors is a risk factor for occurrence of perioperative non-surgical complications in donors of LDLT. After reviewing the data of consecutive LDLT patients who underwent a lobectomy between May 2002 and September 2007, the patients were divided into two groups based on their gender. The studied periopeartive non-surgical complications were hypotension, hypertension, hypoxemia, hypothermia, need for transfusions, respiratory complications (atelectasis, pleural effusion, pneumonia, and pulmonary thromboembolism [PTE]), acute kidney injury (>50% increase in serum creatinine from the baseline), deep vein thrombosis (DVT), and cardiac morbidities. One hundred forty-one donor lobectomies were performed in 59 females (41.8%) and 82 males (58.2%) during the study period. The mean age 10.0 years,8.3 years and 35.5values of females and males were 35.1 respectively (p>0.05). Females had significantly higher body mass index 3.1 kg/m2, p=0.022). Thirty-five3.5 kg/m2 vs 24.2values than males (25.7 females (59.3%) and 53 males (64.6%) had at least one intraoperative complication (p=0.32). The respective incidence of overall postoperative complications in females and males were also similar (59.3% and 64.6%, p=0.320). Both genders were comparable with regards to every single perioperative complication that was included in the study (p>0.05 for all). There were no mortalities in these patients. The length of stay in the hospital was 4.1 days,5.0 days and 7.4significantly longer in females than males (9.1 respectively, p=0.037). In conclusion, our results clearly demonstrate that gender has no impact on the incidence of perioperative non-surgical complications in donors of LDLT.