According world wide data on brain death (GCS:3) cases only one third of them going under organ harvest, one third do not have donor criteria for transplant and in the last one third we cannot take permit from deceased relative to organ dedication. Like this, we have similar condition in Isfahan. Review of causative factor in donor relative permission for organ dedication can help us to spread this culture in the societies. Material and Methods: This retrospective study reviewed all brain death reported cases in 8 last years in Isfahan. All cases divide in three group; organ dedicated, cases who did not fill donor criteria and the third group that we did not have donor relative permission for organ dedication. Third group were divided into 6 subgroup. Results: From May 2000 to May 2008, 372 brain death (GCS: 3) were reported in Isfahan. 35% of cases did not fill donor criteria and 35% were organ dedicator. In third group (30%) who did not underwent dedication causative factor were religious (20%), social and cultural (30%), did not trust to brain death diagnosis (30%), unsatisfied to treatment approach (5%), believe to patient cure (13%) and credit request (2%). Conclusion: According to our data, 30% of brain death case did not dedicate organ so we should waste our supportive policy to dedicated family by material and spiritual concrete, cultural, social and educational programs on public communications. Organ dedication society formation in all city may effective way to decline the third group.