During the past years, quality of life has been taken into account in the analysis of heart transplant results, just like survival. We compared the quality of life of heart transplanted patients before and after cardiac transplantation. The quality of life of 11 patients (9 male, mean age 35 ± 9.6, range 24-54), who underwent cardiac transplantation between May 2006 and August 2008 at Masih Daneshvari Hospital were investigated according to the New York Heart Association (NYHA) functional classification. All eleven cases were classified at stage IV at the time of referral for transplantation. The quality of life in all patients improved substantially following cardiac transplantation, such that all subjects were categorized at stage II and took the ability to return to daily routine life. In conclusions, the results of this small study are comparable with the findings of previous larger investigations which have shown that although it being the last choice of treatment, heart transplantation can significantly improve the quality of life of patients with end-stage heart failure.