Recurrence of multiple myeloma (MM) Presenting as an isolated lesion in the brain has been reported very rarely, Although there have been a few reports of recurrence of MM in the transplanted kidney. Here we report a 60 year- old white lady who had a history of rise in BUN& creatinine about two years ago. Native kidney biopsy revealed "Advanced tubulointerstitial Nephritis" on microscopic examination, so she underwent kidney transplantation. Two years after Renal Transplantation the patient presented with a skull mass which was regarded to be a meningioma. On routine follow- up of the patient, a rise in Bun& creatinine was found. So she was scheduled for a biopsy of the transplanted kidney which revealed "Myeloma cast Nephropathy ". We describe an unusual presentation of Recurrent multiple myeloma mimicking meningioma and discuss the differential diagnosis of the patient's primary disease.