During the past years, Health-Related Quality of Life (HRQOL) has been taken into account in the analysis of heart transplant results, just like survival. The aim of this study was to assess HRQOL and the rate of return to work after cardiac transplantation. During scheduled follow-up visits, a total of 11 patients (9 male, mean age 35 ± 9.6, range 24-54) who underwent cardiac transplantation between May 2006 and August 2008 at Masih Daneshvari Hospital participated in the study. The functional status was assessed with New York Heart Association (NYHA) functional classification and HRQOL was measured with Medical Outcomes Study, 36-item Short Form Survey (SF-36) questionnaire. All eleven cases were classified at class III and IV of NYHA functional classification at the time of referral for transplantation and none of them could work. Three months after surgery, 10 and 1 of recipients reported much better and somewhat better health, respectively and all subjects were assessed to be in class II of NYHA functional classification. All patients went back to work following transplantation. The results of this small study showed that cardiac transplant recipients indicated an improvement in quality of life, general health and the rate of return to work. Some dimensions of health identified in this study may be areas for further investigation.