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Volume: 6 Issue: 4 November 2008 - Supplement - 1



Sleep disturbances are highly prevalent in ESRD patients. In this study we sought to evaluate the associations of poor sleep with several genetic, laboratory, treatment and demographic factors in renal allograft recipients using a validated sleep quality questionnaire. A cross-sectional study was conducted on renal transplant patients. Inclusion criteria were age over 18 years , current stable graft function, and competence to give informed consent. Patients with an elevated serum creatinine level or any concomitant acute disease were excluded from analysis. All patients completed PSQI and Ifudu questionnaires for assessment of sleep quality and morbidity measures, and also their data were extracted from our local registry. Kolmogorov-Smirnov test was used for evaluation of distributions. We used Student’s t-test, and Fisher’s exact test for analyses. Mean total PSQI score for the whole patients was 6.5 ± 2.6. Overall 26 (67%) of patients were diagnosed as ‘poor sleepers’ (PSQI total score ≥5) and the reminding 13 (33%) were ‘good sleepers’. Compared to ‘good sleepers, ‘poor sleepers’ significantly had higher serum phosphate levels and ESRD duration p = 0.05). Hematological disorders were more seen in ‘poor sleepers’ and musculoskeletal disorders had a significant worsening impact on PSQI total score (β = 0.28, p = 0.05). Our study showed that sleep quality in renal transplanted patients is surprisingly low, and demonstrates that poor sleep is associated with co-morbidities, ESRD duration and some serum components. Future studies with more powerful and precise tools and larger sample sizes are necessary for confirming our results.

Volume : 6
Issue : 4
Pages : 124

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Nephrolog and Urologyy Research Center, Baqiyatallah University of Medical Sciences, Tehran, IRAN.