Although several studies have focused on the surgical complications in donors of LDLT, there are scant data regarding the non-surgical complications that may occur in these patients. The aim of this study was to identify the type and frequency of postoperative non-surgical complications after donor hepatectomy in our series of LDLT. We reviewed the data of 141 consecutive LDLT patients who underwent a lobectomy between May 2002 and September 2007. The data included demographic features, intraoperative and postoperative transfusions, amount of administered intraoperative crystalloid and colloids, intraoperative hemodynamics, preoperative and postoperative laboratory values (renal and liver functions), intraoperative and postoperative urine output, and length of hospital stay. Postoperative non-surgical complications such as respiratory complications (atelectasis, pleural effusion, pneumonia, acute lung injury and pulmonary thromboembolism [PTE]), acute kidney injury (>50% increase in serum creatinine from the baseline), deep vein thrombosis (DVT), cardiac morbidities, and need for transfusions were collected using patient charts. One hundred-six (75.2%) of 141 donor lobectomies had at least 1 postoperative non-surgical complication. Respiratory complications, the most commonly noted postoperative non-surgical complication, occurred in 85 (60.3%) of the patients (pleural effusion, n=84, 59.6%; atelectasis, n=47, 33.3%; pneumonia, n=2, 1.4%; and pulmonary thromboembolism, n=1, 0.7%). The other detected postoperative non-surgical complications were need for transfusions (n=63, 44.7%), acute kidney injury (n=4, 2.8%), deep vein thrombosis (n=2, 1.4%), and urinary retention (n=3, 2.1%). There were no mortalities, cardiac morbidities, or transfusion related complications in this group of patients. Except for pneumonia, DVT, and PTE that were treated successfully, other complications were self-limited and no specific therapies were required. In conclusion, postoperative non-surgical complications were commonly detected in our donors of LDLT. However, these problems were mostly mild and self-limited. Further studies are required to evaluate the risk factors and possible preventive measures of these complications.