Hepatoportal Sclerosis (HPS) in one the causes of noncirrhotic portal hypertension. In most of the patients, hepatic synthetic dysfunction does not occur, but rarely they may require liver transplantation. In this study, we report the clinicopathologic characteristics of three patients diagnosed as having HPS after examination of the explanted liver among more than 500 liver transplant cases. All of three patients were labeled as other conditions before transplant such as PSC, and cryptogenic cirrhosis. Small liver volume, significant portal fibrosis and phlebosclerosis may contribute to hepatic synthetic dysfunction in these patients.