During the past decade, improvements in surgical techniques, anesthetic and peri-operative management and more intense antibiotic, antifungal and antiviral prophylaxis have led to more promising outcomes following cardiac transplantation. Objective of this study is to report the incidence of non-surgical complications in patients who received a heart transplant in our center. Clinical data on 11 patients (9 male, mean age 35 ± 9.6, range 24-54), who underwent cardiac transplantation between May 2006 and August 2008 at Masih Daneshvari Hospital were retrospectively reviewed. During the study period, one patient developed aspergillus pneumonia (presenting with pulmonary nodules), pneumonia of unknown origin (also presenting with pulmonary nodules) and cytomegalovirus viremia (presenting with abdominal pain and nausea) at 14 days, 4 days and 1.5 years after transplant surgery, respectively. Furthermore, massive pericardial effusion was detected in two patients that resulted in surgical intervention in one of them. Endomyocardial biopsy in other two patients showed evidence of rejection which was managed successfully with high dose methylprednisolone pulse therapy. No patient died due to non-surgical complications following cardiac transplantation. The results of this small study are comparable with the findings of previous larger investigations which have shown low but real rates of non surgical complications in heart transplanted patients owing to the improvements in surgical techniques and immunosuppressive therapy.