Magnesium, the 2nd most abundant intracellular cation in the human body plays a key role in all enzymatic reactions involving ATP. The presence of hypomagnesemia should be suspected in the following situations: Chronic diarrhea, hypocalcemia, refractory hypokalemia, ventricular arrhythmia. Therapy with cyclosporin (CSA) or tacrolimus increases the urinary Loses of magnesium in renal transplant recipients (RTR). Hypomagnesemia has been reported to be associated with hypertension, glucose intolerance abnormal lipid metabolism, and cardio vascular complication. To analyze the effect of the hypomagnesium early post transplant and to identify its etiological factors. This is a retrospective study. Forty nine Renal transplant recipients (RTR) are selected, following blood tests were performed (Day O, Day7, Day14) total Mg, K, Albumin, Alkaline phosphatase, bicarbonate, FBS, cholesterol, PTH. These patients are assessed clinically in the early post operative periods for convulsion and cardiac (palpitation and chest pain) complications. There is insignificant negative correlation between total magnesium and patients developing convulsions early post operative period at the beginning, middle & end of study (P value 0.06, 0.0078, 0.07 respectively). There is positive significant correlation between hypomagnesemia and improving renal function (beginning, middle and end of study (P value 0.002, 0.01, 0.03) & total cholesterol (at middle and end of study (P value 0.002, 0.05) respectively). There is insignificant positive correlation between total magnesium & K+, Alb, FBS at the beginning, middle and end of study. There is significant negative correlation at the beginning and middle of study between total magnesium and Tacrolimus level (P value 0.04, 0.0002) respectively. Similar relations would not be seen with early cyclosporin or Sirolimus. Non significant negative correlation between total Mg and PTH levels. Hypomagnesemia should be considered as an etiology for convulsion in early post operative period in RTR. Hypomagnesemia is associated with hypokalemia, glucose intolerance, and lipid abnormalities in RTR. Hypomagnesemia is more prominent in patients with Tacrolimus treatment compared to other immunosuppression in early post transplant.