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Volume: 4 Issue: 2 December 2006 - Supplement - 1

FULL TEXT

CHARACTERISTICS OF PATIENTS WITH BANFF BORDERLINE CHANGES IN RENAL ALLOGRAFT BIOPSIES

The aim of this retrospective study was to characterize the patients who experienced Borderline Rejection (BLR) Utilizing Banff criteria for diagnosis of acute rejection, 202 biopsies in 420 patients showed BLR out of 429 biopsies with the diagnosis of acute rejection (47%). Patients with a minimum follow up for two years were enrolled in this study (106 patients). Patients of minimum 2 ys follow up with BLR (n=47, after exclusion of those with associated chronic interstitial fibrosis) were compared to patients with acute cellular rejection Grade I (AR) (n=650) and patients with free rejection episodes (FR) (n=444) regarding the different characteristics. In this group with BLR, the mean age is 25.14 ± 10.29 years with male to female ratio 2.2:1. Patients aged 20 years or less were less frequent in BLR group than other groups which is statistically significant (p=0.001). Significant differences were found in recipient and donor ages, consanguinity, pre transplant blood transfusion, and immunosuppression plan. Most patients in BLR group received triple immunosuppression therapy than other groups (p=0.001). Univariate and multivariate regression analysis of different variables on graft survival in BLR patients revealed that none of them was statistically significant. BLR is a frequent finding in biopsy proven acute rejection after kidney transplantation. Time of occurrence, frequency, presence of chronic changes, treatment or not and response to therapy were not predictors to graft survival.



Volume : 4
Issue : 2
Pages : 91


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