Bone disorders cause important long-term morbidity in renal transplanted recipients. Vitamin D3 (vit D) or 1,25 dihydroxy vitamin D3 with calcium (ca) are used for prophylaxis of osteopathy of these patients. In order to investigate which preparation of vit D is preferred we design this study.
Methods: in a retrospective cross-sectional study, 318 (age 38.9±13.5, F/M 116/202) renal transplanted patients were studied. They were taking various type of vit D (vit D3 or 1,25 dihydroxy vit D3) and ca preparations (calcium carbonate) with different dosage, to prevent progression of osteopathy after kidney transplantation, at least for 3 months before laboratory evaluation. Serum creatinin (cr), ca, albumin (alb), phosphate (ph), PTH, 24 hours urinary ca and cr were measured. Basal characteristics and above mention parameters were compared with Annova.
Results: Mean ± SD of serum cr, ca, ph, PTH were 1.45±0.59, 9.3±0.59, 3.54±0.63 mg/dl, 49.6±73.8ng/ml, respectively and urinary ca was 127.82±75.51 mg/d. There was a strong correlation between serum ph and urinary ca (r=0.91, P=0.01) and also between body weight and urinary ca (r=0.25, P=0.001). There was no correlation between serum or urinary ca with type of vit D and ca preparations.
Conclusion: Concentration of urinary ca is lower than expected (150-200 mg/d) with no correlation between serum and urinary ca. Checking of urinary ca with more frequent intervals is recommended to determine prophylactic dosage of Ca and Vit D regardless of preparation.