The study’s purpose was analysis the influence of histopathologic changes in pre-0 biopsy during organ harvesting and biopsy after graft explantation on graft function and survival in 3-years observation as a major outcome of chronic allograft nephropathy (CAN). Many factors affect long-therm results such as donor quality, renal function undertake, rejection, immunosuppresion, coexisting diseases. One of them is histological damage as a independent predictor of late outcome. It was proved that CAN grade based on histopathologic findings is predictive of further graft survival independently of the serum creatinine level, intestinal fibrosis and tubular atrophy are more prominent features of chronic graft damage than vascular rejection. It was concluded that early protocol biopsies are useful to detect patients at risk of losing their graft due to CAN and they could be used to improve prophylaxis. We analyzed 94 renal biopsies (47 pairs) taken before perfusion during kidney harvesting and multiorgan harvesting as well and 19 biopsies after graft explantation. In histopathologic evaluation we analyzed gromerular mesangial fibrosis, percentage of inflammatory infiltration (focal lymphocytic infiltration), semiquantitive scores of focal and diffuse interstitial fibrosis, tubular lesions (tubular atrophia, tubular necrosis), sclerosis of vessels’ intima, hyalinization of arteries. In postoperative time we analyzed patients condition, urine output, serum concentrations of creatinine, urea, uric acid and ions (Na, K), exigency of postoperative dialysis. Basing on those factors patients were divided on 3 groups: IGF (immediate graft function), DGF (delayed graft function), NGF (no graft function). During 3 years of observation we analyzed 3 groups of patients: living recipients, graft loss, decease with functioning graft. Pre-0 biopsy allows to describe graft’s initial state different from protocol biopsies after transplantation, where histologic findings, dependently on time since operation, are affected by numerous factors: recipients condition, recurrent disease, post-transplant hypertension, immunosuppresion, chronic allograft nephropathy or episode of rejection. Biopsies after explantation in comparison to pre-0 allowed to describe degree of histopathologic changes during graft lifetime. Our study answers the questions: what is average initial state of grafts before transplantation in our material, which and how histological findings, its intensity, frequency and irreversibility correlate with graft long-term function and prediction of delayed graft function.