Angiotensin II receptor antagonists could lower both systemic on intraglomerular pressure and increase functional reserve of transplanted kidney. These effects have been shown by dynamic renal scintigraphy. The aim of this study was determining of the effect of losartan on dynamic tissue perfusion of renal allograft by color Doppler sonography.
Methods: In a randomized, blinded, controlled trail, we compared treatment group by losartan (25 mg two times daily) with no treatment group for changing of duplex sonographic measurements in renal allograft recipients (male=20, female=15) from living donor. The patients in the two groups had similar base-line characteristics. Thirty five patients (losartan group: 16 and control group: 19) completed two months follow up. The mean difference of resistive indices (RI at baseline and after two months) of intrarenal and main artery in the losartan and control groups were (-0.0007±0.038 vs -0.0004±0.36, P=0.6) and (-0.032±0.07 vs 0.001±0.053, P=0.11) respectively. The mean difference of pulsatility indices (PI at baseline and after two months) of arcuate artery and main artery in the losartan and control group were (- 0.082±0.27 vs -0.027±0.34, P=0.63) and (-0.13±0.33 vs -0.81±0.25, P=0.58) respectively. There wasn’t any significant different between changing of acceleration time of main artery in losartan and control group after two months (3.9±10.7 vs 3.8±16 m.sec, P=0.9). We conclude losartan have no effect Doppler sonography indices. How ever, longer follow up is needed to confirm this subject.