Despite advances in immunosuppressant therapy in past decay allograft rejection remains the cause for kidney graft failure. Cytokines are known to be important mediators in renal allograft outcome. The aim of the present study was to ascertain whether IL-4 , IL-10 and TGF-ß cytokine genes polymorphism contribute to the prediction of kidney graft outcome.
Methods: We evaluated single nucleotide polymorphism (SNPs) in IL-4(-1098G/T, -590C/T, -33C/T), IL-10 (-1082A/G, -819C/T, -592A/C) and TGF-ß (codon 10 and 25) in 100 renal transplant recipients and 123 normal healthy control by polymerase chain reaction based on sequence specific primers (PCR-SSP) analysis . Recipients were clinically characterized to rejection episode (RE) and stable graft function (SGF). This study shows the frequencies of IL-4 -33 T allele in the RE, SGF and control group are 7%, 73% and 28% respectively. IL-10 -592 A allele frequency was 39% in RE, 26% in SGF and 28% in control group. TGF-ß codon 10 T allele was 39% in RE, 35% in SGF and 53% in control group. Conclusion: it is suggestive by this study that alleles of TH2 high producer cytokines could effective in the SGF of kidney transplant recipients.