Both deceased donor Liver Transplantation (DDLT) and livingdonor Liver Transplantation (LDLT) are being successfully performed at King Faisal Specialist Hospital and Research Center (KFSH&RC). Herein we present our experience with Liver Transplantation (LT) for Autoimmune Hepatitis (AIH). Patients & Method: At KFSH&RC, and between April 2001 and August 2006, a total of 106 LT procedures were performed (63 DDLTs and 43 LDLTs) in 102 patients (4 re-transplants). Out of the 102 recipients, 14 patients (12%) were transplanted for AIH (13 DDLTs and 1 LDLT). All recipients received FK506 and steroids based immunosuppressive regimens. 14 patients were transplanted for AIH, female/male ratio was 12/2, median age was 22 years (range, 15-35), and median MELD score was 27 (range, 20-37). After a median follow-up period of 446 days (range, 177-1914), the overall patient and graft survival was 93%. Out of 14 patients, only one patient died from primary graft nonfunction, she underwent LDLT with a MELD score of 32, she suffered from sever coagulopathy and bleeding possibly due to small-for-size graft. Out of 14 recipients, 4 patients (28%) had markedly elevated serum CA19-9 levels (range, 217-2800), pre-transplant work up ruled out malignancy, serum CA19-9 normalized in all patients within the first three months post-transplant, histopathologic examination of the explanted livers excluded malignancy, and showed extensive bile ductular proliferation, immunohistochemical stains for CA19-9 showed intense membranous uptake in all bile ductules, proliferative indices using Ki-67 antibody showed surprisingly low levels of proliferation (<1%). Steroids withdrawal failed in all recipients and was always accompanied with almost immediate elevation of liver enzymes, due to either rejection or disease recurrence. In our experience with LT for AIH, patients are usually young females who present with acute deterioration and high MELD scores. Some patients have markedly high CA19-9 in absence of malignancy. Most patients do well after LT and they usually require long-term steroids to prevent rejection and avoid disease recurrence.