Living-donor Liver Transplantation (LDLT) has been successfully performed at King Faisal Specialist Hospital and Research Center (KFSH&RC). Herein we evaluate the donor outcome and morbidity after donor hepatectomy for LDLT at KFSH&RC. At KFSH&RC, and between April 2001 and August 2006, a total of 43 LDLT procedures were performed (35 adult-to-adult donation and 8 adult-to-child donation). The right lobe (segments 5-6) was used in 35 donors, the left lateral segment (segment 2&3) was used in 7 donors, and the whole left lobe without the caudate lobe (segments 2-4) was used in one donor. The middle hepatic vein was included with the right liver graft in 3 donors. All donors were related to their recipients, median graft-recipient weight ratio (GRWR) was 1.3% (range, 0.8%-2.7%); remaining liver volume was >=30% in all donors; and macro-vesicular steatosis was <=20% as estimated by routine preoperative liver biopsy liver biopsy in all donors. All donors were carefully assessed and approved by a social worker, psychologist and at least one senior member of the surgical team. 43 donors were studied; male/female ratio was 33/10; median age was 25 years (range, 18-42); median hospital stay was 6 days (range, 4-14); and only two donors required perioperative blood transfusion. No donor mortality encountered after a median follow-up period of 529 days (range, 8-1354). Donor morbidities were identified in 9 donors (21%) and they included; sever liver dysfunction due to small remaining liver volume in 2 donors treated with supportive treatment; bile leak in one donor treated with ERCP and stenting; biloma in one donor treated with percutaneous drainage, incisional hernia in one donor treated with laparoscopic mesh repair; skin dehiscence in one patient treated with secondary closure; pressure induced alopecia areata in 3 donors that was self-limiting and required no treatment, and neurapraxia of the right arm in one patient treated with physiotherapy. Psychological disturbances were seen in 2 donors that necessitated psychological counseling. As for the LDLT recipient outcome; after a median follow-up period of 529 days (range, 8-1354), the overall patient and graft survival rates were 88% and 79% respectively (4-retransplants using cadaveric organs).In our experience donor hepatectomy is a relatively safe procedure; however, extreme care should be always given by the transplant teams to live donors in order to avoid any distressing morbidity or even, the less likely but more catastrophic, donor mortality.