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Volume: 4 Issue: 2 December 2006 - Supplement - 1

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LIVING-DONOR LIVER TRANSPLANTATION: EARLY RESULTS FROM A SINGLE CENTER

Owing to cadaver organ shortage, living donor liver transplantation (LDLT) has become a critical option for patients with endstage liver disease. Aim of this study was to evaluate outcome of LDLT in a single center in Turkey. Since September 2001, we performed 101LDLTs in 99 patients (73 men and 26 women; mean age, 21.7±19.4 years; range, 0.2-64 years) with end-stage liver disease. Forty-nine right, 16left liver, 36hepatic segments II and III were transplanted. Most donors (46%) were parents of the recipients. Eighteen patients had accompanying hepatocellular carcinoma and cirrhosis. Retransplantation was performed in 2 cases. The mean operative time was 10±2.2 hours,the number of blood transfusions required was 3±3.9 units. The mean time spent in intensive care unit was 3.5±6.9 days. Median graft-to-recipient weight ratio was 1.8±1.1 (range, 0.8-6.1). Ten hepatic arterial thromboses and 12 biliary leaks occurred in the early postoperative period. Three hepatic vein stenoses, 3 portal vein stenoses,6 biliary stenoses developed during the late postoperative period. Mean follow-up was 14.2±10.9 months (range, 1-59 months). During follow-up, we didnot observe any instance of tumor recurrence in any of the HCC cases. At the time of writing, 77patients (77%) were alive with good graft function.In conclusion, complication rates are slightly higher after LDLT compared with cadaveric liver transplantation. However, most complications can be treated with interventional techniques, and LDLT continues to be the life-saving option in countries without satisfactory cadaver donation rates.



Volume : 4
Issue : 2
Pages : 49


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