Liver Transplantation (LT) is nowadays accepted as the definitive therapy for end-stage liver disease. We report our experiences with LT using grafts from living related and cadaveric donors. From April 1998 to March 2006, fifty infants and children underwent LT. We studied pretransplantation status, medical and surgical complications and survival rate in these. There were 33(66%) boys and 17(34%) girls, the mean age of patients was 9.9±4.8 years (range, 0.9-17.7 years) with a mean weight of 33.4±18.4 Kg (range, 7.5-80 Kg). The main indications were cryptogenic cirrhosis (30%) and autoimmune cirrhosis (24%), followed by biliary atresia (22%), Wilson disease (14%), progressive familial intrahepatic cholestasis (4%), fulminant hepatitis (4%) and tyrosinemia (2%). We used living related donor in 14 (28%) and split liver in 5 (10%) cases. The mean follow up of patients was 24.7±22.6 months (range, 1-72 months). The main postoperative complications were acute cellular rejection (44%) and infections (30%), where as chronic rejection seen in 26% of cases. The mortality rate was 24%. Overall 6-month and one year patient survival rate were 91.4 and 63%, respectively. Our results demonstrate that pediatric LT is a feasible undertaking in Iran. Organ shortage in our area led to liberal use of living related and split liver techniques. The overall results of the pediatric LT in Iran are comparable to those of other centers.