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Volume: 4 Issue: 2 December 2006 - Supplement - 1

FULL TEXT

SERUM T-LYMPHOCYTE CYTOKINES CAN NOT PREDICT EARLY ACUTE REJECTION IN RENAL TRANSPLANTATION

Despite numerous studies, the precise role of Th1 / Th2 cytokines in acute renal allograft rejection(AR) remains unclear.
Methods: Serum Th-1 [interleukin- (IL) 2 and interferon-gamma] and Th-2 (IL-4, IL-10) cytokines concentration in 60 concecutive living donor kidney transplant recipients (40 male, mean age 38.82), with (group1) and without (group 2) episodes of AR(in first month after transplantation) were measured on the day before, 7th and 14th day post transplantation using ELISA. Twelve AR was diagnosed among patients (20%). The mean concentration levels for the groups with (G1) and without (G2) AR were: IL-2 pretransplant 12.64±4.11 vs 15.86±4.57 pg/mL, respectively (p=0.382); IL-2 on 7th day posttransplant, 11.23±3.2 4 vs 14.66±4.23pg/mL, respectively (p=0.651); IL-2 on 14th day posttransplant 9.56±2.32 vs 10.73±3.14pg/mL, respectively (p=0.443); IL4 pretransplant20.23±6.63 vs 19.35±5.44 pg/ml (P=0.431); IL4 on 7th day post transplant 24.54±7.24 vs 27.74±10.43 pg/ml (P=0.462); IL4 on14th day post transplant 18.45±5.13 vs 17.32±4.32 (P=0.564); IL10 pretransplant 9.82±3.32 vs 14.±4.46 pg/mL, respectively (p=0.664); IL10 on 7th day posttransplant, 7.55±3.51vs 9.6±3.22 pg/mL, respectively (p=0.654); IL10 on 14th post transplant 10.23±4.12 vs 12.21±3.65 respectively (p=0.436); IFNγ pretransplant 1.66± 0.87 vs 2.14±0.94 (pg/ml) respectively (p=0.722); IFNγ on 7th day post transplant 1.44±0.53 vs 1.45±0.24 (pg/ml) respectively (p=0.413); IFNγ on 14th day post transplant 1.27±0.36 vs 1.63±0.43 (p=0.322). These data shows that there is no correlation between Th1/ Th2 serum cytokines profile and early AR episodes in living donor kidney transplantation.



Volume : 4
Issue : 2
Pages : 43


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