Proinflammatory cytokines have been implicated in the pathogenesis of acute rejection. Single nucleotide polymorphisms (SNPs) of cytokine genes have been shown to influence cytokine plasma level. Cytokines are potent immunomodulatory molecules that act as mediators of the immune response. In the present study, SNPs within INF-γ (UTR +5644 A/T), TNF-α (-308 A/G, -238A/G), IL-2 (- 330T/G, +166T/G) and IL-6 (-174C/G, +565A/G) were analyzed in 100 kidney recipients from living donor and 123 normal healthy control by polymerase chain reaction based on sequence specific primers (PCR-SSP). Recipients were clinically characterized in to two groups the rejection episode (RE) group (30 patients) were defined clinically and confirmed histologically and stable graft function (SGF) group (70 patients) without any sign of rejection episode. This study shows no significant differences in the alleles of INF-γ in the three groups (A allele 55.5% in RE, 53% in SGF and 50.7% in control group). The frequency of A allele in TNF-α at position -308 is 11% in RE, 1.5% in SGF and 14.2% in the control group. At +166 T allele of IL-2 the frequency is 32.5% in RE, 18% in SGF and 21.2% in the control. IL-6 at both studied position there is no significant differences between the three groups. results of these data suggest high producer alleles of pro inflammatory cytokines could effective in the rejection episodes.