Hyperlipidemia is a multifactor event that frequently develops following renal transplantation (RT) and results in worsening of the patient’s prognosis. However the mechanisms are not clear up to now. The aim of this study is to evaluation of hyperlipidemia incidence after RT and its concomitant factors.
Methods: We studied 687 RT recipients in a cross-sectional design to determined frequency of hypercholestrinemia and hypertriglyceridemia before and one month up to one year after renal transplantation and its relation with patient and graft prognosis in two medical centers in Iran from 1988-2004, Cyclosporine was the constant part of immunosuppressive treatment in all study subjects. Results: One and five year graft survival time was 94.23 and 81.34 percent respectively. The prevalence of hypercholestrinemia after transplantation was 59.9% among patients. Mean (±2SE) serum cholesterol level before and after transplantation were 161.15±3.81 and 213.83±4.53 mg/dl respectively, (p=0.000), and 159.99±13.08 and 196.28±19.6 mg/dl respectively for triglycerides levels. There was no significant correlation between dose of CsA, graft and patient survival time and severity of hyperlipidemia (determined by cholesterol and triglycerid levels) in the study. lipids metabolism abnormalities found in this study goes with other similar studies but we could not specify a relation if that with patient or graft survival. In addition, there is maybe a different rout for development of Hyperlipidemia along with Immunosuppressive drugs adverse effect in our study samples.