A high incidence of cancer has been reported following organ transplantation. This study explores the incidence, clinical presentation and outcome of post transplantation Kaposi’ sarcoma (KS) in renal transplant (KTx) recipients. 1290 kidney recipients have been followed up in the centre between May 1972 and December 2005. Of these, 785 were males and 119 were under the age of 18 years. The donor source was a living donor (LD) in 1046 and a cadaver donor (CD) in 244 cases. The medical records of recipients with KS were retrospectively reviewed. Nine instances of KS were diagnosed at 6 months to 192 months [mean 19 months after KTx, with a disease incidence of 0.74%. Recipients with KS were four males and five females, aged 24 to 66 years, and obtained Kidney grafts from seven LD and 2 CD. Kaposi’ sarcoma presented clinically as an isolated cutaneous lesion in four, and as combined cutaneous and visceral lesions in five recipients. Four (44%) recipients are alive for 74 months to 184 months following KS diagnosis. Two patients died (22%) with functioning graft at 1 month to 34 months following KS diagnosis. The remaining three (33%) recipients lost follow up at 6 months to 109 months after detection of KS. In the present series of kidney recipients [1] KS was the second most common form of post KTx cancer (PTLD was the most common form). [2] Incidence tends to be more common in female patients (0.99%) and following CD (0.81%). [3] KS appears early after KTx. [4] Post transplantation KS was associated with reasonable cure rates.